{"id":4145,"date":"2025-10-06T08:35:00","date_gmt":"2025-10-06T07:35:00","guid":{"rendered":"https:\/\/academie-saintonge.org\/?p=4145"},"modified":"2026-07-10T03:37:00","modified_gmt":"2026-07-10T02:37:00","slug":"marie-materna-pour-ses-recherches-sur-les-ressorts-genetiques-de-limmunite","status":"publish","type":"post","link":"https:\/\/academie-saintonge.org\/?p=4145","title":{"rendered":"Marie Materna, pour ses recherches sur les ressorts g\u00e9n\u00e9tiques de l&rsquo;immunit\u00e9"},"content":{"rendered":"\n<style type=\"text\/css\">.article_prix h3{font-weight:bold;}.article_prix p{text-align:justify;}.article_prix figure{display:block;text-align:center;margin:10px 0;}.article_prix figure img{max-width:800px;}.article_prix .lettrine p::first-letter{color: rgba(255, 38, 42, 0.9);font-size: 3.3em;padding: 10px 4px 0 0;float: left;}<\/style>\n\n<div class=\"article_prix\">\n<h2>Prix La Rochelle Universit\u00e9<\/h2>\n\n<h3>Marie Materna, pour ses recherches sur les ressorts g\u00e9n\u00e9tiques de l\u2019immunit\u00e9<\/h3>\n\n<p><b>Rapport\u00a0: <a href=\"\/?p=3393\">Olivier Dubois<\/a><\/b><\/p>\n\n<figure><img decoding=\"async\" src=\"\/wp-content\/uploads\/2026\/07\/Marie-Materna.jpg\" alt=\"Marie Materna\" \/><\/figure>\n\n<p>N\u00e9e \u00e0 Saint-Jean d\u2019Ang\u00e9ly, Marie Materna a \u00e9t\u00e9, tr\u00e8s t\u00f4t, fascin\u00e9e par les m\u00e9canismes invisibles qui r\u00e9gissent le vivant, et par les myst\u00e8res du corps humain. Apr\u00e8s son bac, elle suit un double Master de Biologie Cellulaire, G\u00e9n\u00e9tique et Pathologies, et Master of Engineering en Biologie-Sant\u00e9, puis un stage \u00e0 la Rockefeller University de New York. En 2020, elle rejoint le Laboratoire de G\u00e9n\u00e9tique Humaine des Maladies Infectieuses \u00e0 l\u2019Institut Imagine (H\u00f4pital Necker), sous la responsabilit\u00e9 des Pr. Casanova et Abel.<\/p>\n\n<p>Sa recherche se concentre sur un acteur-cl\u00e9 du d\u00e9veloppement du syst\u00e8me immunitaire : la cha\u00eene pr\u00e9-TCR\u03b1, mol\u00e9cule indispensable \u00e0 la formation de certains globules blancs, les lymphocytes T \u03b1\u03b2. Elle identifie des patients porteurs d\u2019une mutation d\u00e9l\u00e9t\u00e8re dans un g\u00e8ne codant le pr\u00e9-TCR\u03b1. Contre toute attente, ces patients ne pr\u00e9sentent pas de cons\u00e9quence majeure de leur immunit\u00e9 fonctionnelle. Ces observations modifient profond\u00e9ment nos conceptions sur le d\u00e9veloppement de ces lymphocytes.<\/p>\n\n<p>Parall\u00e8lement, Marie Materna a identifi\u00e9 un variant d\u2019un autre g\u00e8ne particuli\u00e8rement pr\u00e9sent dans les populations d\u2019Asie du Sud, facteur de risque de maladies auto-immunes. Cette avanc\u00e9e ouvre la voie \u00e0 des strat\u00e9gies de d\u00e9pistage et de prise en charge des pathologies auto-immunes.<\/p>\n\n<p>Ces travaux ont donn\u00e9 lieu \u00e0 une publication dans la revue <i>Science<\/i>. Ils lui ont m\u00e9rit\u00e9 un prix de l\u2019Institut Imagine et le prix L\u2019Or\u00e9al-UNESCO qui r\u00e9compense les femmes scientifiques. Notre championne a profond\u00e9ment \u00e0 c\u0153ur de promouvoir la transmission des savoirs et la place des femmes dans les carri\u00e8res scientifiques. Attach\u00e9e \u00e0 son d\u00e9partement, elle intervient dans plusieurs \u00e9tablissements comme les lyc\u00e9es de Saint-Jean-d\u2019Ang\u00e9ly, Palissy de Saintes, ou le coll\u00e8ge de Matha.<\/p>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Prix La Rochelle Universit\u00e9 Marie Materna, pour ses recherches sur les ressorts g\u00e9n\u00e9tiques de l\u2019immunit\u00e9 Rapport\u00a0: Olivier Dubois N\u00e9e \u00e0 Saint-Jean d\u2019Ang\u00e9ly, Marie Materna a [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":4100,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[254,3,48,256],"tags":[],"class_list":["post-4145","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-254","category-actualites","category-palmares","category-palmares-2025"],"acf":[],"_links":{"self":[{"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=\/wp\/v2\/posts\/4145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4145"}],"version-history":[{"count":1,"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=\/wp\/v2\/posts\/4145\/revisions"}],"predecessor-version":[{"id":4146,"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=\/wp\/v2\/posts\/4145\/revisions\/4146"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=\/wp\/v2\/media\/4100"}],"wp:attachment":[{"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4145"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academie-saintonge.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}